The Southwest Hematology Oncology Conference: Precision Guided Therapy is a 1-day educational and scientific meeting that will focus on the updates in the biomarker-guided management of patients with common malignancies. This conference will feature experts discussing the latest diagnostic, therapeutic, and supportive care strategies in cancer management. In addition, expert faculty will place key abstract findings from the 2024 ASCO Annual Meeting into a clinical context and discuss how the results may change the current standards of care. The goals of this conference are to review and critically assess practice-changing results of practice-changing clinical data and expert recommendations to incorporate biomarker-guided therapy in the management of patients with cancer.