The “Central Illinois Hematology Oncology Conference: Emphasis on Precision-Guided Management” is an accredited continuous education to improve the care of cancer patients by educating cancer care providers about precision-guided management in hematology and oncology. Regional and national experts in the field will share comprehensive insights into the actionable molecular variations seen in common cancers. The event’s format is tailored to promote active learning, enhance knowledge retention, and encourage practitioners to apply fresh insights into their clinical routines. Through didactics, case-centric discussions, and lively Q&A sessions, attendees can gain clarity, address uncertainties, and interact with the field’s pioneers. This conference aims to provide physicians, physician assistants, nurse practitioners, pharmacists, nurses, and other healthcare professionals with the latest updates in precision-guided management in hematology and oncology. It will highlight a multidisciplinary approach and the integration of new advances in patient-centered care.